Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:1593500 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15937881594351564putative lipoproteinQuickGO ontologyBLASTP
159474615959511206hypothetical proteinBLASTP
15962451596829585ribosomal-protein-alanine acetyltransferaseQuickGO ontologyBLASTP
159683715984471611putative oxidoreductaseQuickGO ontologyBLASTP
159871416002491536hypothetical proteinBLASTP
160074516024061662putative hemolysin activator proteinQuickGO ontologyBLASTP
160255616073314776putative hemolysinQuickGO ontologyBLASTP
160739816091281731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
16097591610334576hypothetical proteinBLASTP
16105661611330765putative copper homeostasis proteinQuickGO ontologyBLASTP
16115231612494972hypothetical proteinBLASTP
16124911613294804hypothetical proteinBLASTP
16134851613880396hypothetical proteinBLASTP
16140601614875816hypothetical proteinBLASTP