Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:1543635 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
154363515457972163hypothetical proteinBLASTP
154637515484862112hypothetical proteinBLASTP
15487331549371639putative sugar-phosphate isomeraseQuickGO ontologyBLASTP
15495061550165660hypothetical proteinBLASTP
15502701550950681putative dehydrogenaseQuickGO ontologyBLASTP
15514041552240837hypothetical proteinBLASTP
15522271553159933hypothetical proteinBLASTP
15531651554070906hypothetical proteinBLASTP
155486115559341074hypothetical proteinBLASTP
15561471556617471hypothetical proteinBLASTP
15566721557094423putative decarboxylaseQuickGO ontologyBLASTP
155737115587561386putative two-component system sensor proteinQuickGO ontologyBLASTP
15587681559460693transcriptional activatorQuickGO ontologyBLASTP
155972515608161092hypothetical proteinBLASTP
15610071561672666hypothetical proteinBLASTP
15616871562382696hypothetical proteinBLASTP
15625911563433843hypothetical proteinBLASTP
15640641564720657hypothetical proteinBLASTP
15647171565547831putative esteraseQuickGO ontologyBLASTP
15655551565953399putative rhodanese-like proteinQuickGO ontologyBLASTP