Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:1420825 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14208251421034210hypothetical proteinBLASTP
14210241421605582hypothetical proteinBLASTP
14216111421775165hypothetical proteinBLASTP
14217941422075282hypothetical proteinBLASTP
14221191422673555hypothetical proteinBLASTP
14226811423103423hypothetical proteinBLASTP
142391914259402022pesticinyersiniabactin receptor proteinQuickGO ontologyBLASTP
142607114276481578yersiniabactin siderophore biosynthetic proteinQuickGO ontologyBLASTP
14276521428440789yersiniabactin biosynthetic protein YbtTQuickGO ontologyBLASTP
142845214295521101yersiniabactin biosynthetic protein YbtUQuickGO ontologyBLASTP
142954914390409492yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
143912814452356108yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
14454261446385960transcriptional regulator YbtAQuickGO ontologyBLASTP
144664214483541713lipoprotein inner membrane ABC-transporterQuickGO ontologyBLASTP
144834114501431803inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
145002814514161389putative signal transducerQuickGO ontologyBLASTP
145144414527481305putative salicylate synthetaseQuickGO ontologyBLASTP
145294214542041263integraseQuickGO ontologyBLASTP
1454366145444176tRNA-AsnQuickGO ontologyBLASTP
14547441455484741pili assembly chaperoneQuickGO ontologyBLASTP
145548114568301350hypothetical proteinBLASTP
145684614594372592fimbrial usher proteinQuickGO ontologyBLASTP
14594861460127642pili assembly chaperoneQuickGO ontologyBLASTP