Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:1147883 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
114788311491271245putative tryptophan-specific transport proteinQuickGO ontologyBLASTP
11495021149756255hypothetical proteinBLASTP
11498251150640816putative short chain oxidoreductaseQuickGO ontologyBLASTP
11506511151601951putative D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
115161311527551143hypothetical proteinBLASTP
11528781153663786transposase for insertion sequence IS1661QuickGO ontologyBLASTP
11537171154253537insertion element IS1661 DNA-binding proteinQuickGO ontologyBLASTP
115455211560481497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
115605211576051554putative carbohydrate kinaseQuickGO ontologyBLASTP
11576251158335711putative ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
115845911595471089putative periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
115965611612301575putative ABC transport ATP-binding subunitQuickGO ontologyBLASTP
11612661162264999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
11623771162832456putative Mut family proteinQuickGO ontologyBLASTP
116309411642271134hypothetical proteinBLASTP
116422411651629391-phosphofructokinaseQuickGO ontologyBLASTP
116517711668771701PTS system fructose-specific IIBC componentQuickGO ontologyBLASTP