Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:650706 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
650706651599894AraC-family regulatory proteinQuickGO ontologyBLASTP
651691652353663DedA-family membrane proteinQuickGO ontologyBLASTP
6525466537571212cystathionine beta-lyaseQuickGO ontologyBLASTP
6542366552731038MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
655283655708426ExbDTolR-family transport proteinQuickGO ontologyBLASTP
6558056573611557membrane proteinQuickGO ontologyBLASTP
657447657959513hypothetical proteinBLASTP
657943658416474membrane proteinQuickGO ontologyBLASTP
658413659183771hypothetical proteinBLASTP
659167660000834hypothetical proteinBLASTP
659997660872876membrane proteinQuickGO ontologyBLASTP
6608696621551287type II secretion proteinQuickGO ontologyBLASTP
662167662709543hypothetical proteinBLASTP
662505663293789hypothetical proteinBLASTP
663591664040450outer membrane secretin family proteinQuickGO ontologyBLASTP
664055664909855hypothetical proteinBLASTP
664906665772867membrane proteinQuickGO ontologyBLASTP
665824666246423membrane proteinQuickGO ontologyBLASTP
666446666904459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
6672576697372481outer membrane usher proteinQuickGO ontologyBLASTP
669755670474720fimbrial chaperone proteinQuickGO ontologyBLASTP
6704996716051107Fimbrial proteinQuickGO ontologyBLASTP
6718176728961080periplasmic binding proteinQuickGO ontologyBLASTP
673752674747996hypothetical proteinBLASTP
674839675417579lipoproteinQuickGO ontologyBLASTP
675420675587168hypothetical protein
675656676489834flagellar biosynthesisexport membrane protein flhA fhiAQuickGO ontologyBLASTP
6764526777531302hypothetical proteinBLASTP
6777406788731134flagellar assembly proteinQuickGO ontologyBLASTP
678873679646774flagellar assembly proteinQuickGO ontologyBLASTP