Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:587689 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5876895898722184glycosyl hydrolaseQuickGO ontologyBLASTP
5899365914621527membrane proteinQuickGO ontologyBLASTP
5914675933681902membrane proteinQuickGO ontologyBLASTP
5933525944011050HlyD family secretion proteinQuickGO ontologyBLASTP
594411594746336hypothetical proteinBLASTP
594743594943201hypothetical proteinBLASTP
5957055969371233aminotransferaseQuickGO ontologyBLASTP
5969305983811452membrane proteinQuickGO ontologyBLASTP
598385598831447hypothetical proteinBLASTP
598828598965138hypothetical proteinBLASTP
598965599591627hypothetical proteinBLASTP
599607599987381translational inhibitor proteinQuickGO ontologyBLASTP
600272600676405translational inhibitor proteinQuickGO ontologyBLASTP
600891601193303hypothetical proteinBLASTP
601453602169717hypothetical proteinBLASTP
602331603263933LysR-family regulatory proteinQuickGO ontologyBLASTP
603714603917204hypothetical proteinBLASTP
603851604225375hypothetical proteinBLASTP
604222604380159hypothetical proteinBLASTP
6052996066811383hypothetical proteinBLASTP
606690607160471hypothetical proteinBLASTP
607187607642456hypothetical proteinBLASTP
607659607949291hypothetical proteinBLASTP
607927608265339hypothetical proteinBLASTP
6087836106211839RNA polymerase sigma factor RpoDQuickGO ontologyBLASTP