Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:442168 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
442168442986819dimethyladenosine transferaseQuickGO ontologyBLASTP
4429794439831005pyridoxal phosphate biosynthetic proteinQuickGO ontologyBLASTP
4439584452621305survival protein SurA precursor peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
4453304477082379organic solvent tolerance protein precursorQuickGO ontologyBLASTP
447857448690834DnaJ-like proteinQuickGO ontologyBLASTP
448988449608621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
449652449777126hypothetical proteinBLASTP
450831451574744hypothetical proteinBLASTP
451919452917999hypothetical proteinBLASTP
452928453488561hypothetical proteinBLASTP
4534884549991512hypothetical proteinBLASTP
455162455680519hypothetical proteinBLASTP
455754456197444hypothetical proteinBLASTP
4562304580741845hypothetical proteinBLASTP
458067459050984hypothetical proteinBLASTP
4590684616562589Clp ATPaseQuickGO ontologyBLASTP