Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3966586 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39662513966589339succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
396658639677191134hypothetical proteinBLASTP
396798639699411956membrane proteinQuickGO ontologyBLASTP
39699433970878936HlyD family secretion proteinQuickGO ontologyBLASTP
39708863971089204membrane proteinQuickGO ontologyBLASTP
39713923972303912lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
39725643973430867lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
397366639761672502insecticial toxinQuickGO ontologyBLASTP
397620839798013594toxin subunitQuickGO ontologyBLASTP
397985839843484491insecticidal toxin complexQuickGO ontologyBLASTP
39844823984784303hypothetical proteinBLASTP
39847973985198402hypothetical proteinBLASTP
39851863985554369hypothetical proteinBLASTP
398563839885952958insecticidal toxinQuickGO ontologyBLASTP