Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3790897 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
379089737930442148formate dehydrogenase HQuickGO ontologyBLASTP
379306737936245584Fe-4S ferrodoxinQuickGO ontologyBLASTP
379364737956622016oxidoreductaseQuickGO ontologyBLASTP
37960823796657576TetR-family regulatory proteinQuickGO ontologyBLASTP
3796802379687776tRNA-PheQuickGO ontologyBLASTP
379731137998662556enhancing factorQuickGO ontologyBLASTP
37998963800063168hypothetical proteinBLASTP
38002933800718426hypothetical proteinBLASTP
38007813801083303transposaseQuickGO ontologyBLASTP
38011543801420267hypothetical proteinBLASTP
380157438026081035L-rhamnose-proton symport proteinQuickGO ontologyBLASTP
38025833802732150hypothetical proteinBLASTP
38027573803629873L-rhamnose operon transcriptional activatorQuickGO ontologyBLASTP
38037623804583822L-rhamnose operon regulatory proteinQuickGO ontologyBLASTP
38045693804709141hypothetical proteinBLASTP
380483938064671629rhamnulokinaseQuickGO ontologyBLASTP
380646438077201257L-rhamnose isomeraseQuickGO ontologyBLASTP
38077333808557825rhamnulose-1-phosphate aldolaseQuickGO ontologyBLASTP
380862438097721149alcohol dehydrogenaseQuickGO ontologyBLASTP
38097863810100315hypothetical proteinBLASTP
38103113810859549single-strand binding proteinQuickGO ontologyBLASTP
381131738141602844excinuclease ABC subunit AQuickGO ontologyBLASTP