Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3648139 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
364813936547896651siderophore biosysnthesis proteinQuickGO ontologyBLASTP
36548053655584780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
365558436566061023transposase for insertion sequence IS100QuickGO ontologyBLASTP
365662036600333414hypothetical proteinBLASTP
366018436622562073TonB-dependent outer membrane receptorQuickGO ontologyBLASTP
366264436638761233peptidaseQuickGO ontologyBLASTP
366395436655101557integral membrane efflux proteinQuickGO ontologyBLASTP
366622936680551827antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
36682643669139876antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
366970236715821881antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
3671685368280211118autotransporter proteinQuickGO ontologyBLASTP