Pre_GI Gene

Some Help

Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3556999 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
355699935593262328ornithine decarboxylaseQuickGO ontologyBLASTP
35591813559333153hypothetical proteinBLASTP
3559830355990576tRNA-PheQuickGO ontologyBLASTP
35601583560406249integraseQuickGO ontologyBLASTP
35604903561125636hypothetical proteinBLASTP
35617333562101369insertion sequence proteinQuickGO ontologyBLASTP
35621553562430276insertion sequence proteinQuickGO ontologyBLASTP
35625263563293768hypothetical proteinBLASTP
356328035655772298kinaseQuickGO ontologyBLASTP
35655933566228636hypothetical proteinBLASTP
35671493567424276insertion sequence proteinQuickGO ontologyBLASTP
356838135705342154hypothetical proteinBLASTP
357061835729662349hypothetical proteinBLASTP
357296335756112649Clp ATPaseQuickGO ontologyBLASTP
35760293576520492hypothetical proteinBLASTP
357660035782611662PALOmpA-family membrane proteinQuickGO ontologyBLASTP
35782613578947687membrane proteinQuickGO ontologyBLASTP
357894435802961353hypothetical proteinBLASTP
358030835818461539hypothetical proteinBLASTP
35818953582395501hypothetical proteinBLASTP
35837953584166372hypothetical proteinBLASTP
35843403584603264insertion element proteinQuickGO ontologyBLASTP
35846713585000330lipoproteinQuickGO ontologyBLASTP
3585279358537496hypothetical proteinBLASTP
35855173586167651membrane proteinQuickGO ontologyBLASTP
35873373587987651N-acylhomoserine lactone synthase YspIQuickGO ontologyBLASTP
35879683588711744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
358927335906491377hypothetical proteinBLASTP