Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3251196 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
325119632524761281citrate synthase GltAQuickGO ontologyBLASTP
32525843253162579heat shock protein GrpEQuickGO ontologyBLASTP
32532863254167882hypothetical proteinBLASTP
325425432559151662DNA repair protein RecNQuickGO ontologyBLASTP
32560293256370342hypothetical proteinBLASTP
32565203256804285hypothetical proteinBLASTP
32567973257231435hypothetical proteinBLASTP
32573803257874495SsrA-binding protein small protein BQuickGO ontologyBLASTP
32585093258967459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
325919132603901200prophage integraseQuickGO ontologyBLASTP
326046932615571089hypothetical proteinBLASTP
326160832632781671hypothetical proteinBLASTP
32634403263667228hypothetical proteinBLASTP
32641303264453324hypothetical proteinBLASTP
32644753265362888DNA-binding prophage proteinQuickGO ontologyBLASTP
32653553265555201transcriptional regulatorQuickGO ontologyBLASTP
32655553266097543prophage proteinQuickGO ontologyBLASTP
32660903267049960prophage DNA primaseQuickGO ontologyBLASTP
326704632681341089regulatory prophage proteinQuickGO ontologyBLASTP
32684833268797315DNA-binding prophage proteinQuickGO ontologyBLASTP
32688033269120318prophage proteinQuickGO ontologyBLASTP
32695353269711177hypothetical proteinBLASTP
326972532707471023transposase for insertion sequence IS100QuickGO ontologyBLASTP
32707473271526780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
32715773271810234hypothetical proteinBLASTP
327214932736331485permeaseQuickGO ontologyBLASTP
3273690327376677tRNA-AspQuickGO ontologyBLASTP
32738793274643765DNA polymerase III epsilon chainQuickGO ontologyBLASTP
32747133275177465ribonuclease HIQuickGO ontologyBLASTP
32752323275951720hypothetical proteinBLASTP