Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:318860 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
318860319804945ribonuclease BNQuickGO ontologyBLASTP
319811320248438hypothetical proteinBLASTP
320322321101780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
3211013221231023transposase for insertion sequence IS100QuickGO ontologyBLASTP
3222573243202064hypothetical proteinBLASTP
3243173256331317hypothetical proteinBLASTP
325700325930231hypothetical proteinBLASTP
326177326644468hypothetical proteinBLASTP
3266573279821326modification methylaseQuickGO ontologyBLASTP
328032328754723hypothetical proteinBLASTP
3287263300991374hypothetical proteinBLASTP
330443330730288hypothetical proteinBLASTP
3313473327591413hypothetical proteinBLASTP
3327563339101155hypothetical proteinBLASTP
3340563351021047M48 peptidase family proteinQuickGO ontologyBLASTP
3351133363091197membrane proteinQuickGO ontologyBLASTP
337015337551537hypothetical proteinBLASTP
337553338428876transcriptional regulatorQuickGO ontologyBLASTP
338421338765345PTS system IIB componentQuickGO ontologyBLASTP
338858339178321PTS system IIB componentQuickGO ontologyBLASTP
3395193406011083PTS system IIC componentQuickGO ontologyBLASTP
3409663435242559phosphoenolpyruvate-protein phosphotransferaseQuickGO ontologyBLASTP