Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3022970 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
302297030246701701PTS system fructose-specific IIBC componentQuickGO ontologyBLASTP
302468530256239391-phosphofructokinaseQuickGO ontologyBLASTP
302562030267531134hypothetical proteinBLASTP
30270153027470456Mut family proteinQuickGO ontologyBLASTP
30275833028581999ABC transport integral membrane subunitQuickGO ontologyBLASTP
302861730301911575ABC transport ATP-binding subunitQuickGO ontologyBLASTP
303030030313881089periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
30315043032214711ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
303223430337871554carbohydrate kinaseQuickGO ontologyBLASTP
303379130352871497aldehyde dehydrogenaseQuickGO ontologyBLASTP
303563930367811143hypothetical proteinBLASTP
30367933037743951D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
30377543038569816short-chain oxidoreductaseQuickGO ontologyBLASTP
30386383038892255hypothetical proteinBLASTP
303926730405111245tryptophan-specific transport proteinQuickGO ontologyBLASTP
30406153041187573elongation factor PQuickGO ontologyBLASTP
304132730425201194mannonate dehydrataseQuickGO ontologyBLASTP
304310530445771473D-mannonate oxidoreductaseQuickGO ontologyBLASTP
30447213045464744transcriptional regulatory proteinQuickGO ontologyBLASTP