Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:2773139 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
277313927743051167hypothetical proteinBLASTP
27743602775064705GTP cyclohydrolase IQuickGO ontologyBLASTP
277520627763571152hypothetical proteinBLASTP
27764932777362870LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
277763627787751140alcohol dehydrogenaseQuickGO ontologyBLASTP
27787962779638843esteraseQuickGO ontologyBLASTP
278019127825512361membrane proteinQuickGO ontologyBLASTP
278255327838151263hypothetical proteinBLASTP
27838172784485669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
278449527858051311heme-binding proteinQuickGO ontologyBLASTP
278634027876141275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
27876162788386771molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
278852227897301209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
27897742790427654hypothetical proteinBLASTP
279065527924181764ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
27929332793556624hypothetical proteinBLASTP
279376827951351368hypothetical proteinBLASTP