Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:2652825 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
265282526551162292ferrichrome receptor proteinQuickGO ontologyBLASTP
26554602655978519PASQuickGO ontologyBLASTP
265618726575421356hypothetical proteinBLASTP
26577642658042279hypothetical proteinBLASTP
26582642659103840rRNA guanine-N1--methyltransferaseQuickGO ontologyBLASTP
26594982660253756hypothetical proteinBLASTP
26603442660553210cold shock proteinQuickGO ontologyBLASTP
26605962660712117hypothetical proteinBLASTP
26617142662313600hypothetical proteinBLASTP
266261826639911374aromatic amino acid transport proteinQuickGO ontologyBLASTP
26642282664539312hypothetical proteinBLASTP
26645822664881300hypothetical proteinBLASTP
26651442665419276hypothetical proteinBLASTP
26660022666235234membrane proteinQuickGO ontologyBLASTP
26663262666565240hypothetical proteinBLASTP
26671212667507387AraC-family transcriptional regulatory proteinQuickGO ontologyBLASTP
26675892667753165membrane proteinQuickGO ontologyBLASTP
266840926701271719ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
26702302671081852hypothetical proteinBLASTP
26713182671602285hypothetical proteinBLASTP
26719922672804813hypothetical proteinBLASTP
2672982267305776tRNA-AsnQuickGO ontologyBLASTP
26732052673462258ThuR regulatory protein for trehalosemaltose transportQuickGO ontologyBLASTP
26734782673771294IS100 transposaseQuickGO ontologyBLASTP
26738232674257435IS100 transposaseQuickGO ontologyBLASTP
267425726752791023transposase for insertion sequence IS100QuickGO ontologyBLASTP
26752932676180888hypothetical proteinBLASTP