Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:2517538 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25173112517652342ABC-type sugar transport systems ATPase componentsQuickGO ontologyBLASTP
25175382518428891binding-protein-dependent transport system ATP-binding componentQuickGO ontologyBLASTP
25184532519280828binding-protein-dependent transport system inner membrane componentQuickGO ontologyBLASTP
25192732520133861binding-protein-dependent transport system inner membrane componentQuickGO ontologyBLASTP
252020025214681269exported solute-binding proteinQuickGO ontologyBLASTP
252149825225111014oxidoreductaseQuickGO ontologyBLASTP
25226502522865216hypothetical protein
25231732523970798GntR-family putative transcriptional regulatory proteinQuickGO ontologyBLASTP
25239872524148162hypothetical proteinBLASTP
25243152524521207hypothetical proteinBLASTP
25249392525373435hypothetical proteinBLASTP
25253852525954570hypothetical proteinBLASTP
25263722526710339transposaseQuickGO ontologyBLASTP
25267102527570861hypothetical proteinBLASTP
252761825286941077hypothetical proteinBLASTP
25287602529050291hypothetical proteinBLASTP
25290312529303273hypothetical proteinBLASTP
25293342529693360hypothetical proteinBLASTP
25296902529989300hypothetical proteinBLASTP
25300062530293288hypothetical proteinBLASTP
25309402531245306hypothetical proteinBLASTP
25316692531809141major tail sheath proteinQuickGO ontologyBLASTP
25319202532339420hypothetical proteinBLASTP
25324112533370960transposaseQuickGO ontologyBLASTP
25335902533934345hypothetical proteinBLASTP
25339602534139180hypothetical proteinBLASTP
25345432534716174hypothetical proteinBLASTP
25354762535703228replicative DNA helicaseQuickGO ontologyBLASTP
25357722536329558hypothetical proteinBLASTP
2536627253671286tRNA-LeuQuickGO ontologyBLASTP
2536723253679674tRNA-CysQuickGO ontologyBLASTP
2536849253692476tRNA-GlyQuickGO ontology
25370692537617549CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
253767625395291854excinuclease ABC subunit CQuickGO ontologyBLASTP
25395012540157657response regulator proteinQuickGO ontologyBLASTP