Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:2411161 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
241116124124441284lipoproteinQuickGO ontologyBLASTP
24130982413967870gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
24140162414552537thermosensitive gluconokinaseQuickGO ontologyBLASTP
24146302415097468hypothetical proteinBLASTP
241546524166551191hypothetical proteinBLASTP
241689124183541464NADH dehydrogenase I chain NQuickGO ontologyBLASTP
241836124198931533NADH dehydrogenase I chain MQuickGO ontologyBLASTP
241993324217771845NADH dehydrogenase I chain LQuickGO ontologyBLASTP
24217742422076303NADH dehydrogenase i chain kQuickGO ontologyBLASTP
24220732422618546NADH dehydrogenase I chain JQuickGO ontologyBLASTP
24226312423173543NADH Dehydrogenase I chain IQuickGO ontologyBLASTP
24231882424165978NADH dehydrogenase I chain HQuickGO ontologyBLASTP
242416224269062745NADH dehydrogenase I chain GQuickGO ontologyBLASTP
242699324283781386NADH dehydrogenase I chain FQuickGO ontologyBLASTP
24283752428938564NADH dehydrogenase I chain EQuickGO ontologyBLASTP
242894124307371797NADH dehydrogenase I chain CDQuickGO ontologyBLASTP
24308782431555678NADH dehydrogenase I chain BQuickGO ontologyBLASTP
24316572432157501NADH dehydrogenase I chain AQuickGO ontologyBLASTP
24328352433767933LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP