Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:2366500 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
236656323676601098tartrate dehydrogenaseQuickGO ontologyBLASTP
23677512368692942putativeLlysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
236893923699431005LacI-family transcriptional regulatory proteinQuickGO ontologyBLASTP
23700762371068993sugar transport system permease proteinQuickGO ontologyBLASTP
237106523725551491sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
23725952373512918sugar binding protein precursorQuickGO ontologyBLASTP
237368723749131227zinc-binding dehydrogenaseQuickGO ontologyBLASTP
23754962376218723hypothetical proteinBLASTP
23763602376902543hypothetical proteinBLASTP
23771402378078939membrane proteinQuickGO ontologyBLASTP
23783942378918525outer membrane proteinQuickGO ontologyBLASTP
23791532379257105hypothetical protein
23793232380210888membrane proteinQuickGO ontologyBLASTP
23802262380723498hypothetical proteinBLASTP
23807462381522777puative trans-aconitate methyltransferaseQuickGO ontologyBLASTP
23817792382282504DNA-binding proteinQuickGO ontologyBLASTP
238260223837291128hypothetical proteinBLASTP