Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:2337336 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
233733623383911056hypothetical proteinBLASTP
23385382339362825sugar ABC transporter permease proteinQuickGO ontologyBLASTP
23393632340238876sugar ABC transporter permease proteinQuickGO ontologyBLASTP
234034723416331287solute-binding proteinQuickGO ontologyBLASTP
234190523429451041LacI-family transcriptional regulatory proteinQuickGO ontologyBLASTP
234296223443501389phosphomannomutaseQuickGO ontologyBLASTP
234445023455291080mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
23456572345782126hypothetical proteinBLASTP
23457942346324531hypothetical proteinBLASTP
23465972347094498hypothetical proteinBLASTP
23471492347553405hypothetical proteinBLASTP
23476952347862168hypothetical proteinBLASTP
23480652348262198hypothetical proteinBLASTP
234827223503052034hypothetical proteinBLASTP
23509692351220252hypothetical proteinBLASTP
23514652351974510hypothetical proteinBLASTP
235197623595237548hemolysinQuickGO ontologyBLASTP
235972723614151689hemolysin activator proteinQuickGO ontologyBLASTP