Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1842500 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
184258018436261047selenide water dikinaseQuickGO ontologyBLASTP
184368518456131929DNA topoisomerase IIIQuickGO ontologyBLASTP
18456101845900291hypothetical proteinBLASTP
18459131846299387pyrophosphohydrolaseQuickGO ontologyBLASTP
18463971847203807exodeoxyribonuclease IIIQuickGO ontologyBLASTP
18480131848873861LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
1849381184946585tRNA-TyrQuickGO ontologyBLASTP
184974518509531209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
18509161851785870hypothetical proteinBLASTP
18518691852333465hypothetical proteinBLASTP
185366718546831017response regulatorQuickGO ontologyBLASTP
185499018563361347nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP
18567711857178408DNA-binding protein HnsQuickGO ontologyBLASTP
18579281858518591thymidine kinaseQuickGO ontologyBLASTP
18588871859666780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
185966618606881023transposase for insertion sequence IS100QuickGO ontologyBLASTP
186122818639032676aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
18647101865354645membrane proteinQuickGO ontologyBLASTP
186619218678291638periplasmic oligopeptide-binding protein precursorQuickGO ontologyBLASTP
18679161868836921oligopeptide transport system permease proteinQuickGO ontologyBLASTP
18688551869760906oligopeptide transport system permease proteinQuickGO ontologyBLASTP
186977218707731002oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP
187077018717711002oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP
18723321872547216hypothetical proteinBLASTP
18728461873199354hypothetical proteinBLASTP
187333418747941461cardiolipin synthetaseQuickGO ontologyBLASTP
18758411876380540attachment invasion locus protein precursorQuickGO ontologyBLASTP
18763551876483129hypothetical proteinBLASTP
18766011876864264hypothetical proteinBLASTP
18769801877225246hypothetical proteinBLASTP
18774481877744297hypothetical proteinBLASTP
18780451878803759TonB proteinQuickGO ontologyBLASTP
187883918800471209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
18801951880644450acyl-CoA thioester hydrolaseQuickGO ontologyBLASTP