Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1669921 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
166992116720832163hypothetical proteinBLASTP
167266116747722112membrane proteinQuickGO ontologyBLASTP
16750191675657639sugar-phosphate isomeraseQuickGO ontologyBLASTP
16757921676451660hypothetical proteinBLASTP
16765561677236681dehydrogenaseQuickGO ontologyBLASTP
16775771678527951hypothetical proteinBLASTP
16785141679446933hypothetical proteinBLASTP
16794521680357906hypothetical proteinBLASTP
168114816822211074hypothetical proteinBLASTP
16824341682904471hypothetical proteinBLASTP
16829591683381423decarboxylaseQuickGO ontologyBLASTP
168365816850431386two-component system sensor proteinQuickGO ontologyBLASTP
16850551685747693transcriptional activatorQuickGO ontologyBLASTP
168601216871031092hypothetical proteinBLASTP
16872941687959666hypothetical proteinBLASTP
16879741688669696membrane proteinQuickGO ontologyBLASTP
16888781689720843hypothetical proteinBLASTP
16903511691007657hypothetical proteinBLASTP
16910041691834831esteraseQuickGO ontologyBLASTP