Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1556581 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15565811557456876sulfate transport system permease protein CysWQuickGO ontologyBLASTP
155744615585371092sulfate transport ATP-binding proteinQuickGO ontologyBLASTP
15587081559586879cysteine synthase BQuickGO ontologyBLASTP
155983115610631233hypothetical proteinBLASTP
15614441562151708two-component response regulatorQuickGO ontologyBLASTP
156214815636921545two-component sensor histidine kinaseQuickGO ontologyBLASTP
156392515653431419membrane proteinQuickGO ontologyBLASTP
156605115672321182aminotransferaseQuickGO ontologyBLASTP
15672661567457192hypothetical proteinBLASTP
156745415684851032peptidaseQuickGO ontologyBLASTP
156882215702821461permeaseQuickGO ontologyBLASTP
157034215719881647pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
157224315742792037ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
157428315754881206HlyD family secretion proteinQuickGO ontologyBLASTP