Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1440371 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14403711441327957membrane proteinQuickGO ontologyBLASTP
14413761441600225hypothetical proteinBLASTP
144171714430961380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
144326614447291464inosine-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
144490914464861578GMP synthaseQuickGO ontologyBLASTP
14468611447319459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
14474791447958480hypothetical proteinBLASTP
14479821448380399hypothetical proteinBLASTP
14484441448863420hypothetical proteinBLASTP
14489011449296396hypothetical proteinBLASTP
14497521450453702membrane proteinQuickGO ontologyBLASTP
145047814516861209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
14516981451976279hypothetical proteinBLASTP
14520351452502468membrane proteinQuickGO ontologyBLASTP
14530241453824801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
14538861454632747hypothetical proteinBLASTP
14546041454774171hypothetical proteinBLASTP
14550051455514510hypothetical proteinBLASTP
14558011456691891diacylglycerol kinaseQuickGO ontologyBLASTP
145732714587211395proteaseQuickGO ontologyBLASTP
14589961459334339hypothetical proteinBLASTP
14594711460190720two-component system response regulatorQuickGO ontologyBLASTP
14602001460457258ATP-binding region ATPase-like proteinQuickGO ontologyBLASTP
146046914615841116hypothetical proteinBLASTP
146161514630121398membrane proteinQuickGO ontologyBLASTP