Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1317109 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
131710913188271719urease alpha subunitQuickGO ontologyBLASTP
13191231319818696urease accessory proteinQuickGO ontologyBLASTP
13198401320526687urease accessory proteinQuickGO ontologyBLASTP
13206531321315663urease accessory proteinQuickGO ontologyBLASTP
13213121322145834hypothetical proteinBLASTP
13221711322278108urease accessory proteinQuickGO ontologyBLASTP
13224701323462993urea transporterQuickGO ontologyBLASTP
132361113246691059nickel transport proteinQuickGO ontologyBLASTP
13248381325167330hypothetical proteinBLASTP
132578513269601176potassium channel proteinQuickGO ontologyBLASTP
13270581327462405membrane proteinQuickGO ontologyBLASTP
13274781327858381membrane proteinQuickGO ontologyBLASTP
13279471328126180hypothetical proteinBLASTP
13288991329216318PTS system cellobiose-specific IIB componentQuickGO ontologyBLASTP
132922713305881362PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
13307551331102348PTS system cellobiose-specific IIA componentQuickGO ontologyBLASTP
13311511331981831cel operon repressorQuickGO ontologyBLASTP
13320331332794762hypothetical proteinBLASTP
13330891333457369hypothetical proteinBLASTP
13339521334479528negative regulator of replication initiationQuickGO ontologyBLASTP
133451013361951686phosphoglucomutaseQuickGO ontologyBLASTP
13364131336526114hypothetical proteinBLASTP
13365691336811243hypothetical proteinBLASTP
13369391337367429membrane proteinQuickGO ontologyBLASTP
13374621338091630two-component regulatory protein response regulator KdpEQuickGO ontologyBLASTP
133838413411102727two-component regulatory protein sensor kinase KdpDQuickGO ontologyBLASTP