Pre_GI Gene

Some Help

Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1195614 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
119561411979952382beta-glucosidaseQuickGO ontologyBLASTP
11981541198684531membrane proteinQuickGO ontologyBLASTP
119867712008842208membrane proteinQuickGO ontologyBLASTP
12009201201081162hypothetical proteinBLASTP
120133612025441209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
12026231202931309hypothetical proteinBLASTP
12029461203527582hypothetical proteinBLASTP
120406212059781917putative autotransporter proteinQuickGO ontologyBLASTP
12067871207026240hypothetical proteinBLASTP
12070651207316252hypothetical proteinBLASTP
12073401207912573membrane proteinQuickGO ontologyBLASTP
12079241208325402membrane proteinQuickGO ontologyBLASTP
12085581208998441hypothetical proteinBLASTP
12089521209155204hypothetical proteinBLASTP
12092271209808582hypothetical proteinBLASTP
12104811210726246DNA-binding proteinQuickGO ontologyBLASTP
121093912133022364hypothetical proteinBLASTP
12134971213955459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
121407012200485979membrane proteinQuickGO ontologyBLASTP