Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1002453 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10016601002460801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
10024531003082630Na-translocating NADH-quinone reductase subunit DQuickGO ontologyBLASTP
10030891003685597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
100370110049241224NADH-uniquinone oxidoreductase subunit FQuickGO ontologyBLASTP
100490810059871080thiamine biosynthesis lipoproteinQuickGO ontologyBLASTP
10060001006227228hypothetical proteinBLASTP
10064711007418948hypothetical proteinBLASTP
100777410088321059DNA-damage-inducible protein PQuickGO ontologyBLASTP
100894610104061461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
10122811013192912LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
101365210152561605carbohydrate-binding proteinQuickGO ontologyBLASTP
10161851016643459xanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
101677010180171248hypothetical proteinBLASTP
10180771018478402curlin genes regulatory proteinQuickGO ontologyBLASTP
101865510197581104glutamate 5-kinaseQuickGO ontologyBLASTP
101976810210271260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
10213641022113750hypothetical proteinBLASTP
10222961022565270membrane proteinQuickGO ontologyBLASTP
10225431022746204hypothetical proteinBLASTP
10226941023332639hypothetical proteinBLASTP
10240621024619558methyltransferaseQuickGO ontologyBLASTP
10248661025390525shikimate kinase IIQuickGO ontologyBLASTP
10258801026167288hypothetical proteinBLASTP
10264031027314912recombination associated protein RdgCQuickGO ontologyBLASTP