Pre_GI Gene

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Host: NC_008120 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008120:62000 Yersinia pestis Antiqua plasmid pMT, complete sequence

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
62072639581887porphyrin biosynthetic proteinQuickGO ontologyBLASTP
6399764776780transposaseQuickGO ontologyBLASTP
64776657981023transposaseQuickGO ontologyBLASTP
6582566397573porphyrin biosynthetic proteinQuickGO ontologyBLASTP
6650766719213hypothetical proteinBLASTP
6698767373387hypothetical proteinBLASTP
6736867712345integraseQuickGO ontologyBLASTP
6773568472738integraseQuickGO ontologyBLASTP
6923269744513F1 capsule antigenQuickGO ontologyBLASTP
69825723262502F1 capsule anchoring proteinQuickGO ontologyBLASTP
7235173127777F1 chaperone proteinQuickGO ontologyBLASTP
7343774360924F1 operon positive regulatory proteinQuickGO ontologyBLASTP
74709759171209transposaseQuickGO ontologyBLASTP
76386774081023transposaseQuickGO ontologyBLASTP
7760777924318hypothetical proteinBLASTP
7797778177201transposaseQuickGO ontologyBLASTP
7878479239456hypothetical proteinBLASTP
79484812471764murine toxinQuickGO ontologyBLASTP
8132581813489hypothetical proteinBLASTP
8255382828276hypothetical proteinBLASTP
8285183792942hypothetical proteinBLASTP
8385884478621resolvaseQuickGO ontologyBLASTP
8500485231228hypothetical proteinBLASTP
85533867381206partitioning protein AQuickGO ontologyBLASTP
8673587706972partitioning protein BQuickGO ontologyBLASTP
8784387989147hypothetical proteinBLASTP
88091894821392DNA-binding proteinQuickGO ontologyBLASTP