Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:761234 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
761234762121888IS629 ORF2QuickGO ontologyBLASTP
762121762396276IS629 ORF1QuickGO ontologyBLASTP
762514763017504IS1 ORF2QuickGO ontologyBLASTP
763110763292183putative IS1 encoded proteinQuickGO ontologyBLASTP
763483764052570repressor proteinQuickGO ontologyBLASTP
764178764399222hypothetical proteinBLASTP
765010765849840IS911 ORF2QuickGO ontologyBLASTP
765949766497549putative DNA adenine methylaseQuickGO ontologyBLASTP
7664947689082415possible endonucleaseQuickGO ontologyBLASTP
769189769494306putative damage-inducible proteinQuickGO ontologyBLASTP
7697877714361650putative phage-related proteinQuickGO ontologyBLASTP
771438772301864putative phage-related proteinQuickGO ontologyBLASTP
772408772752345probable capsid portal protein fragmentQuickGO ontologyBLASTP
772843773439597probable capsid portal protein fragmentQuickGO ontologyBLASTP
7734397752051767terminase ATPase subunitQuickGO ontologyBLASTP
775348776181834putative capsid scaffolding proteinQuickGO ontologyBLASTP
7761987772561059major capsid proteinQuickGO ontologyBLASTP
777260777910651terminase endonuclease subunitQuickGO ontologyBLASTP
778006778470465putative capsid completion proteinQuickGO ontologyBLASTP
778470778673204probable phage tail proteinQuickGO ontologyBLASTP
778677778892216possible secretory proteinQuickGO ontologyBLASTP
778873779385513putative lysozyme protein R of prophage CP-933KQuickGO ontologyBLASTP
779387779764378hypothetical proteinBLASTP
779761780189429putative regulatory proteinQuickGO ontologyBLASTP