Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:4403070 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
440307044051602091putative receptorQuickGO ontologyBLASTP
44053944405618225hypothetical proteinBLASTP
44062874407126840IS911 ORF2QuickGO ontologyBLASTP
44071204407602483hypothetical proteinBLASTP
44081554408331177putative IS1-encoded proteinQuickGO ontologyBLASTP
44084244408927504IS1 ORF2QuickGO ontologyBLASTP
44093164410188873hypothetical proteinBLASTP
44104004411380981hypothetical proteinBLASTP
441144544126591215hypothetical proteinBLASTP
44125714413296726hypothetical proteinBLASTP
44147434415345603FimBQuickGO ontologyBLASTP
44158234416419597FimEQuickGO ontologyBLASTP
44168964417444549major type 1 subunit fimbrinQuickGO ontologyBLASTP
44174104418048639fimbrial proteinQuickGO ontologyBLASTP
44180854418810726periplasmic chaperoneQuickGO ontologyBLASTP
44215234422053531fimbrial morphologyQuickGO ontologyBLASTP
44220664422569504fimbrial morphologyQuickGO ontologyBLASTP
44225894423383795minor fimbrial subunitQuickGO ontologyBLASTP
44234234424310888IS629 ORF2QuickGO ontologyBLASTP
44243104424576267IS629 ORF1QuickGO ontologyBLASTP
442558244267661185mannonate hydrolaseQuickGO ontologyBLASTP
442684744283071461D-mannonate oxidoreductaseQuickGO ontologyBLASTP
44285224429295774regulator for uxu operonQuickGO ontologyBLASTP