Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:4156841 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
415684141587511911putative enzymeQuickGO ontologyBLASTP
415889241599231032hypothetical proteinBLASTP
41599424160265324formate dehydrogenase HQuickGO ontologyBLASTP
416042641624231998hypothetical proteinBLASTP
41626644162981318ribose 5-phosphate isomerase BQuickGO ontologyBLASTP
41630504163379330hypothetical proteinBLASTP
41635264164284759phosphonate metabolismQuickGO ontologyBLASTP
41642864164735450PhnOQuickGO ontologyBLASTP
41647224165279558ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
416527941664151137PhnMQuickGO ontologyBLASTP
41664124167092681ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
41672034167961759ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
41679584168803846PhnJQuickGO ontologyBLASTP
416879641698541059PhnIQuickGO ontologyBLASTP
41698544170438585PhnHQuickGO ontologyBLASTP
41704354170887453PhnGQuickGO ontologyBLASTP
41708884171613726putative transcriptional regulatorQuickGO ontologyBLASTP
41716344172413780membrane channel protein component of Pn transporterQuickGO ontologyBLASTP
417253941735551017periplasmic binding protein component of Pn transporterQuickGO ontologyBLASTP
41735804174368789ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
41745014174944444hypothetical proteinBLASTP
41751044175439336hypothetical proteinBLASTP
41756964175926231putative IS1 encoded proteinQuickGO ontologyBLASTP
41760014176504504IS1 ORF2QuickGO ontologyBLASTP
417998941814911503low affinity transport system proline permease IIQuickGO ontologyBLASTP