Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:4119771 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
411977141206438734-hydroxybenzoate-octaprenyltransferaseQuickGO ontologyBLASTP
41206564121264609chorismate lyaseQuickGO ontologyBLASTP
412169741228241128putative transposaseQuickGO ontologyBLASTP
412308841242781191hypothetical proteinBLASTP
41246094124776168putative IS1 encoded proteinQuickGO ontologyBLASTP
41248694125372504IS1 ORF2QuickGO ontologyBLASTP
41254484125951504hypothetical proteinBLASTP
41263534127066714diadenosine tetraphosphataseQuickGO ontologyBLASTP
41271774127593417hypothetical proteinBLASTP
41275974127953357hypothetical proteinBLASTP
412798841308102823excision nuclease subunit AQuickGO ontologyBLASTP
41310644131600537ssDNA-binding proteinQuickGO ontologyBLASTP
413170141330171317IS4 ORFQuickGO ontologyBLASTP
41330024133841840IS2 ORF2QuickGO ontologyBLASTP
41338654134230366IS2 ORF1QuickGO ontologyBLASTP
41344744134824351hypothetical proteinBLASTP
41351854135925741hypothetical proteinBLASTP
41359074136077171putative IS1 encoded proteinQuickGO ontologyBLASTP
41361704136673504IS1 ORF2QuickGO ontologyBLASTP
413672641383751650hypothetical proteinBLASTP