Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:3637832 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36370123637845834hypothetical proteinBLASTP
363910536401301026threonine dehydrogenaseQuickGO ontologyBLASTP
3640140364133611972-amino-3-ketobutyrate CoA ligaseQuickGO ontologyBLASTP
36415503642482933ADP-L-glycero-D-mannoheptose-6-epimeraseQuickGO ontologyBLASTP
364249236435381047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
36435423644522981heptosyl transferase IQuickGO ontologyBLASTP
364459236458451254lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
364695936479841026UDP-galactosegalactosyl LPS alpha12-galactosyltransferaseQuickGO ontologyBLASTP
36480103648702693WaaYQuickGO ontologyBLASTP
36487123649707996lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
364972436507401017UDP-D-galactoseglucosyllipopolysaccharide- alpha-13-D-galactosyltransferaseQuickGO ontologyBLASTP
36507563651553798RfaPQuickGO ontologyBLASTP
365154636526701125glucosyltransferase IQuickGO ontologyBLASTP
365266736537251059lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
3654138365541512783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
36554233655902480putative enzyme of lipopolysaccharide synthesisQuickGO ontologyBLASTP
36559413656750810formamidopyrimidine DNA glycosylaseQuickGO ontologyBLASTP
3656848365701516850S ribosomal subunit protein L33QuickGO ontologyBLASTP
3657036365727223750S ribosomal subunit protein L28QuickGO ontologyBLASTP
36574893658163675DNA repair proteinQuickGO ontologyBLASTP
365825736595491293DfpQuickGO ontologyBLASTP
36595303659985456deoxyuridinetriphosphataseQuickGO ontologyBLASTP
36600503660688639putative transcriptional regulatorQuickGO ontologyBLASTP
36607253661366642orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
36614323662148717RNase PHQuickGO ontologyBLASTP