Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:2699500 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
26995462699776231hypothetical proteinBLASTP
269996527011701206hypothetical proteinBLASTP
27011702701613444hypothetical proteinBLASTP
27016642702470807putative enzymeQuickGO ontologyBLASTP
270254727036441098membrane-bound lytic murein transglycosylase AQuickGO ontologyBLASTP
2703853270392977tRNA-MetQuickGO ontology
2703963270403977tRNA-MetQuickGO ontology
2704072270414877tRNA-MetQuickGO ontology
27042272705174948putative phosphoglycerate dehydrogenaseQuickGO ontologyBLASTP
27054122705915504IS1 ORF2QuickGO ontologyBLASTP
27059902706172183putative IS1 encoded proteinQuickGO ontologyBLASTP
27061432706619477putative isomeraseQuickGO ontologyBLASTP
270658827077961209cystathionine beta-lyaseQuickGO ontologyBLASTP
27094082710055648hypothetical proteinBLASTP
271049127118341344putative amidaseQuickGO ontologyBLASTP
271197627133071332N-acetylglutamate synthaseQuickGO ontologyBLASTP
271336927151951827ATP-dependent dsDNAssDNA exonuclease V subunitQuickGO ontologyBLASTP
271519527187373543ATP-dependent dsDNAssDNA exonuclease V subunitQuickGO ontologyBLASTP
271873027216182889protease IIIQuickGO ontologyBLASTP