Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:2376974 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23769742377345372IS1 ORF2QuickGO ontologyBLASTP
23781382378893756lipoprotein precursorQuickGO ontologyBLASTP
23791872380119933putative transportQuickGO ontologyBLASTP
2380195238026975tRNA-ArgQuickGO ontology
23806762381197522IS911 ORF2QuickGO ontologyBLASTP
238123623824621227D-serine dehydrataseQuickGO ontologyBLASTP
238257023841081539multidrug resistance protein YQuickGO ontologyBLASTP
238410823852711164multidrug resistance protein KQuickGO ontologyBLASTP
23856872386301615putative positive transcription regulatorQuickGO ontologyBLASTP
238630623898993594putative sensor for regulator EvgAQuickGO ontologyBLASTP
238995523911391185putative enzymeQuickGO ontologyBLASTP
23911742392118945putative receptor proteinQuickGO ontologyBLASTP
239218823938821695putative enzymeQuickGO ontologyBLASTP
239393623951861251putative enzymeQuickGO ontologyBLASTP
23956992396331633hypothetical proteinBLASTP
23966272396902276hypothetical proteinBLASTP
23969792397221243hypothetical proteinBLASTP
23975082398494987putative heat shock proteinQuickGO ontologyBLASTP
239898624002241239putative aminotransferaseQuickGO ontologyBLASTP