Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:1038000 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10381561038458303IS600 ORF1QuickGO ontologyBLASTP
10385991039312714IS600 ORF2QuickGO ontologyBLASTP
10395051039708204unknown protein encoded within prophageQuickGO ontologyBLASTP
10406661041169504IS1 ORF2QuickGO ontologyBLASTP
10412621041429168putative IS1 encoded proteinQuickGO ontologyBLASTP
10414881042087600putative membrane protein precursorQuickGO ontologyBLASTP
104215110435661416putative tail fiber proteinQuickGO ontologyBLASTP
10435171044140624putative tail component of prophageQuickGO ontologyBLASTP
104432010459631644invasion plasmid antigenQuickGO ontologyBLASTP
10462791046710432hypothetical proteinBLASTP
10469491047122174putative IS1 encoded proteinQuickGO ontologyBLASTP
10472151047718504IS1 ORF2QuickGO ontologyBLASTP
10480231048235213hypothetical proteinBLASTP
10482101049049840IS911 ORF2QuickGO ontologyBLASTP
10502811050841561putative cytochromeQuickGO ontologyBLASTP
10511541051804651hypothetical proteinBLASTP
10520621052697636hypothetical proteinBLASTP
10542901055009720putative 2-component transcriptional regulatorQuickGO ontologyBLASTP
105500910563671359putative 2-component sensor proteinQuickGO ontologyBLASTP
10566721057175504IS1 ORF2QuickGO ontologyBLASTP
10572681057438171putative IS1 encoded proteinQuickGO ontologyBLASTP
10574791057976498putative outer membrane porin protein C precurserQuickGO ontologyBLASTP
10584591058899441IS2 ORF2QuickGO ontologyBLASTP
10592091059865657IS911 ORF2QuickGO ontologyBLASTP
10600571060353297IS2 ORF2QuickGO ontologyBLASTP