Pre_GI Gene

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Host: NC_007608 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007608:97092 Shigella boydii Sb227 plasmid pSB4_227, complete sequence

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
97092981801089hypothetical proteinBLASTP
9818599135951VirKQuickGO ontologyBLASTP
99200100144945MsbB2QuickGO ontologyBLASTP
100298100906609IS630 ORFQuickGO ontologyBLASTP
100985101488504IS1 ORF2QuickGO ontologyBLASTP
101798102211414membrane protein fragmentQuickGO ontologyBLASTP
102211102930720hypothetical proteinBLASTP
102618102845228plasmid maintenance proteinQuickGO ontologyBLASTP
102927103346420oriT nicking and unwinding protein fragmentQuickGO ontologyBLASTP
1033061082044899oriT nicking and unwinding protein fragmentQuickGO ontologyBLASTP
108224108970747F pilin acetylation proteinQuickGO ontologyBLASTP
109025109585561FinOQuickGO ontologyBLASTP
109716109928213hypothetical proteinBLASTP
110172110633462hypothetical proteinBLASTP
110679110888210putative regulatorQuickGO ontologyBLASTP
110927111517591hypothetical proteinBLASTP
111757112017261RepBQuickGO ontologyBLASTP
112308113165858RepAQuickGO ontologyBLASTP
114273114497225hypothetical proteinBLASTP
1146531158521200IS1294 transposaseQuickGO ontologyBLASTP
116065116412348IS629 ORF1QuickGO ontologyBLASTP
1168041182581455OspC2QuickGO ontologyBLASTP
1183971196051209IS1294 transposaseQuickGO ontologyBLASTP
120130120432303hypothetical proteinBLASTP
120423120905483hypothetical proteinBLASTP
120973121275303IS600 ORF1QuickGO ontologyBLASTP
121311121499189IS600 ORF2QuickGO ontologyBLASTP
121539121904366IS629 ORF2QuickGO ontologyBLASTP
121915122253339IS911 ORF1QuickGO ontologyBLASTP
122280123119840IS911 ORF2QuickGO ontologyBLASTP