Pre_GI Gene

Some Help

Host: NC_007607 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007607:87000 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8708488025942UDP-sugar hydrolaseQuickGO ontologyBLASTP
8803088980951VirKQuickGO ontologyBLASTP
8904589989945MsbB2QuickGO ontologyBLASTP
9016390831669putative transposaseQuickGO ontologyBLASTP
9097391281309hypothetical proteinBLASTP
9134291545204hypothetical proteinBLASTP
9163792329693IS186 ORF1QuickGO ontologyBLASTP
9237093083714IS600 ORF2QuickGO ontologyBLASTP
9322493526303IS600 ORF1QuickGO ontologyBLASTP
93565950791515hypothetical proteinBLASTP
9496195374414hypothetical proteinBLASTP
9537496093720TrbHQuickGO ontologyBLASTP
9578196008228plasmid maintenance proteinQuickGO ontologyBLASTP
9609096509420oriT nicking and unwinding protein fragmentQuickGO ontologyBLASTP
965171007104194oriT nicking and unwinding protein fragmentQuickGO ontologyBLASTP
100659101351693putative DNA helicase I fragmentQuickGO ontologyBLASTP
101371102117747F pilin acetylation proteinQuickGO ontologyBLASTP
102172102732561FinOQuickGO ontologyBLASTP
102863103075213hypothetical proteinBLASTP
103259103561303hypothetical proteinBLASTP
103496103741246IS1 ORF2QuickGO ontologyBLASTP
104009104221213putative iso-IS1 orfQuickGO ontologyBLASTP
104290104520231hypothetical proteinBLASTP
104623104811189putative regulatorQuickGO ontologyBLASTP
104850104963114hypothetical protein
104960105355396iso-IS1 ORF2QuickGO ontologyBLASTP
105382105654273iso-IS1 ORF1QuickGO ontologyBLASTP
105714106214501hypothetical proteinBLASTP
106454106714261RepBQuickGO ontologyBLASTP
107005107862858RepAQuickGO ontologyBLASTP
10860510870096hypothetical proteinBLASTP
1089721101801209IS1294 transposaseQuickGO ontologyBLASTP
110161110433273hypothetical proteinBLASTP
1104271119711545invasion plasmid antigen fragmentQuickGO ontologyBLASTP
112011112199189IS600 ORF2QuickGO ontologyBLASTP
112235112537303IS600 ORF1QuickGO ontologyBLASTP
112605113087483hypothetical proteinBLASTP
113078113368291hypothetical proteinBLASTP
113794114456663IS100 ORF2QuickGO ontologyBLASTP
1145111158031293IS1294 transposaseQuickGO ontologyBLASTP
115784116056273hypothetical proteinBLASTP
116076116663588ISSfl4 ORF1QuickGO ontologyBLASTP
116800116973174hypothetical proteinBLASTP
1173141187681455OspC3QuickGO ontologyBLASTP
119107119409303IS600 ORF1QuickGO ontologyBLASTP
119550120263714IS600 ORF2QuickGO ontologyBLASTP
120388120630243IS1353 transposaseQuickGO ontologyBLASTP
120685121038354IS1353 transposaseQuickGO ontologyBLASTP
1212281223431116putative transposaseQuickGO ontologyBLASTP
121613122101489hypothetical proteinBLASTP
1224321236281197ISSfl2 ORFQuickGO ontologyBLASTP