Pre_GI Gene

Some Help

Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:674265 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
674265675170906oligopeptide abc transporter permease proteinQuickGO ontologyBLASTP
675189676157969oligopeptide abc transporter permease proteinQuickGO ontologyBLASTP
676172677098927oligopeptide abc transporter atp-binding proteinQuickGO ontologyBLASTP
6783896797381350glycerol-3-phosphate transporterQuickGO ontologyBLASTP
680011680469459transcriptional regulator marr familyQuickGO ontologyBLASTP
682227683198972ribose operon repressorQuickGO ontologyBLASTP
683212684108897ribokinaseQuickGO ontologyBLASTP
684105684500396ribose abc transporter proteinQuickGO ontologyBLASTP
6846186860031386ribose abc transporter atp-binding proteinQuickGO ontologyBLASTP
686006686941936ribose abc transporter permease proteinQuickGO ontologyBLASTP
686956687882927ribose abc transporter ribose-binding proteinQuickGO ontologyBLASTP
687917688564648transaldolaseQuickGO ontologyBLASTP
6888816912802400immune inhibitor a metalloproteaseQuickGO ontologyBLASTP
691599691940342hypothetical proteinBLASTP
6919786931501173multidrug resistance protein putativeQuickGO ontologyBLASTP