Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:5197854 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
51978545198732879hypothetical proteinBLASTP
51989145199462549hypothetical proteinBLASTP
51994535199638186hypothetical proteinBLASTP
519969252008671176serine proteaseQuickGO ontologyBLASTP
52009315201725795metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
52017095202551843yyci proteinQuickGO ontologyBLASTP
520253252038481317yych proteinQuickGO ontologyBLASTP
520384552056861842sensory box histidine kinase yycgQuickGO ontologyBLASTP
52056905206397708dna-binding response regulator yycfQuickGO ontologyBLASTP
5206801520687373tRNA-PheQuickGO ontology
5207011520708272tRNA-GluQuickGO ontologyBLASTP
5207096520717176tRNA-LysQuickGO ontologyBLASTP
520731152086001290adenylosuccinate synthetaseQuickGO ontologyBLASTP
520881652101771362replicative DNA helicaseQuickGO ontologyBLASTP
5210205521065144750S ribosomal protein L9QuickGO ontologyBLASTP
521064852126211974dhh subfamily 1 proteinQuickGO ontologyBLASTP
52127005213638939hypothetical proteinBLASTP
5213716521394923430S ribosomal protein S18QuickGO ontologyBLASTP
52139955214513519single-strand DNA-binding proteinQuickGO ontologyBLASTP
5214543521483329130S ribosomal protein S6QuickGO ontologyBLASTP
521502552161251101gtp-binding protein ychfQuickGO ontologyBLASTP
52162415216438198hypothetical proteinBLASTP
52164595217340882mechanosensitive ion channel family proteinQuickGO ontologyBLASTP
52176005218196597hypothetical proteinBLASTP
52182175218987771stage 0 sporulation protein jQuickGO ontologyBLASTP
52190615219822762sporulation initiation inhibitor protein sojQuickGO ontologyBLASTP