Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:5006319 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
500631950088832565hypothetical proteinBLASTP
50088835009146264hypothetical proteinBLASTP
500939950106971299glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
501064850118891242glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
501218350131841002mbl proteinQuickGO ontologyBLASTP
50133465013744399stage iii sporulation protein dQuickGO ontologyBLASTP
50140235014403381lipoprotein putativeQuickGO ontologyBLASTP
50145595014693135hypothetical proteinBLASTP
50148355015740906stage ii sporulation proteinQuickGO ontologyBLASTP
50159025016606705abc transporter permease protein putativeQuickGO ontologyBLASTP
50166065017448843abc transporter atp-binding proteinQuickGO ontologyBLASTP
501876550197841020stage ii sporulation protein dQuickGO ontologyBLASTP
501999250212961305UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50213365022046711hypothetical proteinBLASTP
50220925022328237hypothetical proteinBLASTP
502269450242141521NADH dehydrogenase subunit NQuickGO ontologyBLASTP
502421650257091494NADH dehydrogenase subunit MQuickGO ontologyBLASTP
502570650275201815NADH dehydrogenase subunit LQuickGO ontologyBLASTP
50275985027912315NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
50279055028429525NADH dehydrogenase subunit JQuickGO ontologyBLASTP
50284265028845420NADH dehydrogenase subunit IQuickGO ontologyBLASTP
502887150298721002NADH dehydrogenase subunit HQuickGO ontologyBLASTP
502987250309721101NADH dehydrogenase delta subunitQuickGO ontologyBLASTP