Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4877500 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
48775104878466957thioredoxin reductaseQuickGO ontologyBLASTP
487855148800621512tpr domain proteinQuickGO ontologyBLASTP
48802024880714513bacterial transferase hexapeptide domain proteinQuickGO ontologyBLASTP
48807384881388651hydrolase haloacid dehalogenase-like familyQuickGO ontologyBLASTP
48814564882268813prolipoprotein diacylglyceryl transferaseQuickGO ontologyBLASTP
48822934883222930HPr kinasephosphorylaseQuickGO ontologyBLASTP
48833794883759381hypothetical proteinBLASTP
48838744884323450hypothetical proteinBLASTP
488438348872592877excinuclease ABC subunit AQuickGO ontologyBLASTP
488726548892411977excinuclease ABC subunit BQuickGO ontologyBLASTP
488940248905591158transposase is605 familyQuickGO ontologyBLASTP
48909774891408432lipoprotein putativeQuickGO ontologyBLASTP
48914544892074621hypothetical proteinBLASTP
48920714892832762transcriptional regulator merr familyQuickGO ontologyBLASTP
48929324893081150hypothetical proteinBLASTP
48931764893568393hypothetical proteinBLASTP
48935654893786222hypothetical proteinBLASTP
48937994894011213dna-binding proteinQuickGO ontologyBLASTP
489433148953531023hypothetical proteinBLASTP
48955044896397894transcriptional regulator lysr familyQuickGO ontologyBLASTP
48964494896814366transcriptional regulator merr familyQuickGO ontologyBLASTP
48968194897364546fmn reductase nadph-dependentQuickGO ontologyBLASTP
489763048992641635macrolide efflux pump putativeQuickGO ontologyBLASTP
489974549014601716abc transporter atp-bindingpermease proteinQuickGO ontologyBLASTP
490177249029561185hypothetical proteinBLASTP
490306649044751410carboxyl-terminal proteaseQuickGO ontologyBLASTP
49046214905514894cell division abc transporter permease protein ftsxQuickGO ontologyBLASTP
49055044906148645cell division abc transporter atp-binding protein ftseQuickGO ontologyBLASTP
49064774906800324cytochrome c-551QuickGO ontologyBLASTP
49070554907237183hypothetical proteinBLASTP
490848049109872508translocaseQuickGO ontologyBLASTP
49112644911806543ribosomal subunit interface proteinQuickGO ontologyBLASTP
49121304912327198cold shock protein cspcQuickGO ontologyBLASTP
49124544913026573comf operon protein 3QuickGO ontologyBLASTP
491315849145071350comf operon protein 1QuickGO ontologyBLASTP
491463549159451311endopeptidase lyte putativeQuickGO ontologyBLASTP
49161974916511315hypothetical proteinBLASTP
49165824916704123hypothetical proteinBLASTP
49166854917527843degv family proteinQuickGO ontologyBLASTP
49177674918402636conserved hypothetical protein tigr00257QuickGO ontologyBLASTP
491847749196041128transcription antiterminator lytr familyQuickGO ontologyBLASTP