Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4744870 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
47448704745100231hypothetical proteinBLASTP
47451534745683531lipoprotein putativeQuickGO ontologyBLASTP
47458274746474648pap2 family proteinQuickGO ontologyBLASTP
474653147475441014hypothetical proteinBLASTP
47475674748517951L-lactate dehydrogenaseQuickGO ontologyBLASTP
47487634749011249spore coat protein f-related proteinQuickGO ontologyBLASTP
47490254749210186hypothetical proteinBLASTP
47493574750040684caax amino terminal protease family proteinQuickGO ontologyBLASTP
47506584751206549transcriptional regulator putativeQuickGO ontologyBLASTP
47512104751932723metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
475207147538551785acyl-coa dehydrogenaseQuickGO ontologyBLASTP
47540084754124117hypothetical proteinBLASTP
475413047553021173acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
4755324475770523823-hydroxyacyl-coa dehydrogenaseenoyl-coa hydrataseisomerase family proteinQuickGO ontologyBLASTP
4757803475790199hypothetical proteinBLASTP
47579414758087147hypothetical proteinBLASTP
47581754759014840d-alanyl-d-alanine carboxypeptidase family proteinQuickGO ontologyBLASTP
47590374759954918proline dehydrogenase family proteinQuickGO ontologyBLASTP
47602644760509246hypothetical proteinBLASTP
47605584760860303conserved hypothetical protein tigr00106QuickGO ontologyBLASTP
476093847629382001methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
47631274763885759hypothetical proteinBLASTP
476391647657991884cell wall surface anchor family proteinQuickGO ontologyBLASTP