Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4507742 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45077424508065324transcriptional regulator arsr familyQuickGO ontologyBLASTP
45080664508497432hypothetical proteinBLASTP
45088704509148279hypothetical proteinBLASTP
45091834509365183hypothetical proteinBLASTP
45093674509603237hypothetical proteinBLASTP
45098744510320447transcriptional regulator card familyQuickGO ontologyBLASTP
45103804511165786glucose-1-dehydrogenaseQuickGO ontologyBLASTP
45111794512036858glucose uptake proteinQuickGO ontologyBLASTP
45120734512492420hypothetical proteinBLASTP
45125864512819234molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
45128224513286465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
45132834513798516molybdopterin-guanine dinucleotide biosynthesis protein mobbQuickGO ontologyBLASTP
451376845150571290molybdopterin biosynthesis protein moeaQuickGO ontologyBLASTP
45151414515626486molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
451566545166781014molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
451788445192931410collagen triple helix repeat domain proteinQuickGO ontologyBLASTP
45194674519790324hypothetical proteinBLASTP
45198114520035225hypothetical proteinBLASTP
45201134520418306rhodanese-like domain proteinQuickGO ontologyBLASTP
45206194520801183hypothetical proteinBLASTP
452085145219751125homoserine O-acetyltransferaseQuickGO ontologyBLASTP
452212845243712244spore germination protein gerhaQuickGO ontologyBLASTP
452438945254831095spore germination protein gerhbQuickGO ontologyBLASTP
452545945265381080spore germination protein gerhcQuickGO ontologyBLASTP