Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4474000 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
44741004474396297mind family atpase domain proteinQuickGO ontologyBLASTP
44744784474714237hypothetical proteinBLASTP
44747044475078375hypothetical proteinBLASTP
44751134476111999catabolite control protein aQuickGO ontologyBLASTP
447664044776561017lipoprotein putativeQuickGO ontologyBLASTP
44777744478100327hypothetical proteinBLASTP
44781004478612513hypothetical proteinBLASTP
447880044799151116aminopeptidase putativeQuickGO ontologyBLASTP
44799524480386435lipoprotein putativeQuickGO ontologyBLASTP
44804024480584183hypothetical proteinBLASTP
44805814480985405hypothetical proteinBLASTP
44810774481631555ribosomal-protein-serine acetyltransferase putativeQuickGO ontologyBLASTP
448182844831381311UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
448339144845091119nicotinate phosphoribosyltransferaseQuickGO ontologyBLASTP
448457144885063936ftskspoiiie family proteinQuickGO ontologyBLASTP
44887284489072345hypothetical proteinBLASTP
44895074490121615trna binding domain protein putativeQuickGO ontologyBLASTP
44901184490930813hypothetical proteinBLASTP
44910104491324315thioredoxin family proteinQuickGO ontologyBLASTP
44914084491917510hypothetical proteinBLASTP
449215944932321074peptidase m42 familyQuickGO ontologyBLASTP
44933814493692312hypothetical proteinBLASTP
44939284494782855metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
44948524495505654tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
44957384496016279hypothetical proteinBLASTP
44960204496811792aminoglycoside phosphotransferase family proteinQuickGO ontologyBLASTP