Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4400152 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
440015244014441293isocitrate dehydrogenaseQuickGO ontologyBLASTP
440160544027201116citrate synthaseQuickGO ontologyBLASTP
44031414403602462hypothetical proteinBLASTP
440404444051411098hypothetical proteinBLASTP
44057274406116390fxsa cytoplasmic membrane protein putativeQuickGO ontologyBLASTP
440631644080731758pyruvate kinaseQuickGO ontologyBLASTP
440812744090869606-phosphofructokinaseQuickGO ontologyBLASTP
44092154410189975acetyl-CoA carboxylase alpha subunitQuickGO ontologyBLASTP
44101774411046870acetyl-CoA carboxylase beta subunitQuickGO ontologyBLASTP
44112324411876645transcriptional regulator gntr familyQuickGO ontologyBLASTP
441189144130991209malate dehydrogenase putativeQuickGO ontologyBLASTP
441323344165593327DNA polymerase III subunit alphaQuickGO ontologyBLASTP
44166774417015339hypothetical proteinBLASTP
44170124417515504hypothetical proteinBLASTP
44175674418499933dhh subfamily 1 proteinQuickGO ontologyBLASTP