Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4251773 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4251773425208130950S ribosomal protein L21QuickGO ontologyBLASTP
425224742536231377ribonuclease rnerng familyQuickGO ontologyBLASTP
42537064254566861stage iv sporulation protein fbQuickGO ontologyBLASTP
42545594255305747stage iv sporulation protein faQuickGO ontologyBLASTP
42554394256236798septum site-determining protein mindQuickGO ontologyBLASTP
42562394256925687septum formation inhibitorQuickGO ontologyBLASTP
42569614257506546rod shape-determining protein mredQuickGO ontologyBLASTP
42575214258372852rod shape-determining protein mrecQuickGO ontologyBLASTP
425841442594331020rod shape-determining protein mrebQuickGO ontologyBLASTP
42595924260269678DNA repair protein RadCQuickGO ontologyBLASTP
42603164260891576Maf-like proteinQuickGO ontologyBLASTP
42611124262074963stage ii sporulation protein b putativeQuickGO ontologyBLASTP
426224042635411302folylpolyglutamate synthaseQuickGO ontologyBLASTP
426363542662802646valyl-tRNA synthetaseQuickGO ontologyBLASTP
426667642677011026hypothetical proteinBLASTP
42677644268747984stage vi sporulation protein d putativeQuickGO ontologyBLASTP
426885742701461290glutamate-1-semialdehyde aminotransferaseQuickGO ontologyBLASTP
42701464271135990delta-aminolevulinic acid dehydrataseQuickGO ontologyBLASTP
42711564271908753uroporphyrinogen-III synthetaseQuickGO ontologyBLASTP
42719104272839930porphobilinogen deaminaseQuickGO ontologyBLASTP
42728554273688834hemx proteinQuickGO ontologyBLASTP