Pre_GI Gene

Some Help

Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4176462 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
417646241790652604aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
417932541804581134cystathionine beta-lyaseQuickGO ontologyBLASTP
41804624181385924o-acetylserine lyaseQuickGO ontologyBLASTP
418146841821636965-methylthioadenosineS-adenosylhomocysteine nucleosidaseQuickGO ontologyBLASTP
41821784182816639hypothetical proteinBLASTP
41829534183168216hypothetical proteinBLASTP
41832044183851648hypothetical proteinBLASTP
418396841857221755penicillin-binding proteinQuickGO ontologyBLASTP
41858154186291477transcription elongation factor GreAQuickGO ontologyBLASTP
41865704187208639uridine kinaseQuickGO ontologyBLASTP
418722641885061281peptidase u32 familyQuickGO ontologyBLASTP
41885254189373849peptidase u32 familyQuickGO ontologyBLASTP
41894624190103642o-methyltransferase family proteinQuickGO ontologyBLASTP
419030641913611056conserved hypothetical protein tigr00247QuickGO ontologyBLASTP
41915944191872279hypothetical proteinBLASTP
41918854192298414Holliday junction resolvase-like proteinQuickGO ontologyBLASTP
41923024192568267hypothetical proteinBLASTP
419264541952872643alanyl-tRNA synthetaseQuickGO ontologyBLASTP
41957704196039270hypothetical proteinBLASTP
419615141972181068hypothetical proteinBLASTP
41973954197607213hypothetical proteinBLASTP
41976434197771129hypothetical proteinBLASTP
41977904197978189hypothetical proteinBLASTP
419810642004182313helicase putativeQuickGO ontologyBLASTP