Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4117071 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41166044117074471hypothetical proteinBLASTP
411707141192152145hdig domain proteinQuickGO ontologyBLASTP
41194094120368960phoh family proteinQuickGO ontologyBLASTP
412037241215711200sporulation proteinQuickGO ontologyBLASTP
41215614121671111hypothetical proteinBLASTP
41217484122041294hypothetical proteinBLASTP
41221504122593444gatbyqey domain proteinQuickGO ontologyBLASTP
4122609412278217430S ribosomal protein S21QuickGO ontologyBLASTP
412311341244651353hypothetical proteinBLASTP
41244724125128657conserved hypothetical protein tigr00046QuickGO ontologyBLASTP
41253674126305939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
412633441274491116chaperone protein dnajQuickGO ontologyBLASTP
412765441294891836molecular chaperone DnaKQuickGO ontologyBLASTP
41295164130082567grpe proteinQuickGO ontologyBLASTP
413019741312131017heat-inducible transcription repressorQuickGO ontologyBLASTP
413134741324831137coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
41325394132913375hypothetical proteinBLASTP
413304541348681824GTP-binding protein LepAQuickGO ontologyBLASTP
41350794135441363hypothetical proteinBLASTP
413544141365471107germination protease precursorQuickGO ontologyBLASTP
4136720413698626730S ribosomal protein S20QuickGO ontologyBLASTP
413706941380791011hypothetical proteinBLASTP