Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3694940 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
369494036960101071proline dipeptidase putativeQuickGO ontologyBLASTP
36959903696133144hypothetical proteinBLASTP
36961303696498369hypothetical proteinBLASTP
36965143696879366hypothetical proteinBLASTP
369704636984311386hypothetical proteinBLASTP
36985983698852255hypothetical proteinBLASTP
36995943700226633orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
37002233700939717orotidine 5-phosphate decarboxylaseQuickGO ontologyBLASTP
37009243701853930dihydroorotate dehydrogenaseQuickGO ontologyBLASTP
37018503702629780dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
370262637058443219carbamoyl-phosphate synthase large subunitQuickGO ontologyBLASTP
370582937069261098carbamoyl-phosphate synthase small subunitQuickGO ontologyBLASTP
370692337082091287dihydroorotaseQuickGO ontologyBLASTP
37081933709107915aspartate carbamoyltransferase catalytic subunitQuickGO ontologyBLASTP
370925637105391284uracil permeaseQuickGO ontologyBLASTP
37106863711228543pyrimidine regulatory protein PyrRQuickGO ontologyBLASTP
37123443712802459signal peptidase IIQuickGO ontologyBLASTP
37129273713241315hypothetical proteinBLASTP
371341237161772766isoleucyl-tRNA synthetaseQuickGO ontologyBLASTP
37165253717031507cell-division initiation protein divivaQuickGO ontologyBLASTP
37171213717888768s4 domain proteinQuickGO ontologyBLASTP
37179043718167264ylmg proteinQuickGO ontologyBLASTP
37181743718644471ylmf proteinQuickGO ontologyBLASTP
37186643719338675conserved hypothetical protein tigr00044QuickGO ontologyBLASTP
37193353720153819conserved hypothetical protein tigr00726QuickGO ontologyBLASTP